Charcot collapse of the foot and ankle presents its most dramatic and debilitating form with diabetics. This softening of the bones in the foot is most prevalent with diabetics experiencing neuropathy (nerve damage) and poor circulation.
Because of neuropathy, some diabetics can no longer feel when their foot has become irritated or the skin punctured. In extreme cases, a blister can quickly develop into a serious infection.
High glucose levels (diabetes) damage blood vessels, and decrease circulation to the feet. Reduced blood flow weakens bone so people with diabetes are at a high risk for breaking bones in the feet.