Expert Insights On Treatment Options For Cystic Lesions Of The Talus

Ankle Arthritis, University Foot and Ankle Institute, Los Angeles

As published in Podiatry Today:

An osteochondral lesion is an injury or fracture to the chondral surface or underlying subchondral bone. These lesions occur in the talus and are generally secondary to single or multiple traumatic events. Traumatic events can cause multiple mechanisms of injury including shearing, fracture, avulsion and compaction. These injuries can result in varying degrees of partial or complete detachment of the chondral fragment.

Osteochondral lesions can lead to underlying subchondral cyst formation. Damaged cartilage can allow a unidirectional invasion of fluid from the ankle joint into the underlying subchondral bone. Over time, osteolysis and subchondral cyst formation occur. As cystic changes occur, the increase in fluid pressure results in increasing pain due to the innervation of the subchondral bone.

These lesions cause ankle joint pain that is associated with weightbearing and activity. Often, patients recognize symptoms in a delayed fashion as the injury generally occurs secondary to other trauma. Generally, the patient presents with an aching ankle months after a prior injury or ankle sprain. Early diagnosis is important as this can lead to improved patient outcomes. Over time, these lesions can impair range of motion, cause stiffness, limit function and also cause catching, locking and clicking of the joint.

Keys To An Accurate Diagnosis

Physical examination should include evaluation of local tenderness and swelling. Assess range of motion to evaluate for pain and limitation as well as clicking or catching of the joint. Frequently, these lesions occur with ligamentous injury and one should thoroughly examine for instability.

One may obtain radiographic imaging to evaluate for cystic or chondral changes, but bear in mind that these studies are insufficient for complete diagnosis. Berndt and Harty developed a classification system for radiographic staging of osteochondral talar lesions. Loomer and colleagues added a stage V to this system, which is important as this stage considers the involvement of a subchondral cyst.

Order magnetic resonance imaging (MRI) when there are incidents of chronic ankle pain. The use of MRI enables the evaluation of cartilage damage, subchondral cystic or edematous changes, and effusions as well as ligamentous assessment. Utilize computed tomography (CT) scans to further determine the true size of the cystic lesion as MRIs can lead one to overestimate bony edema.

What Are The Most Effective Treatment Options?

Non-surgical treatment consists of non-weightbearing and immobilization for approximately six weeks. One can utilize non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory modalities during this time period. Patients should have physical therapy following immobilization to gradually increase range of motion, weightbearing and activity.

After the failure of conservative care, a combination of MRI and CT findings along with intraoperative arthroscopic evaluation are necessary to determine the best treatment option.

Arthroscopy is a key component in treating osteochondral and cystic lesions of the talus. When possible, utilize arthroscopic treatment as this allows for direct visualization of the pathology while avoiding an arthrotomy and potential complication. A wide variety of treatment strategies exist for osteochondral defects of the talus and these treatments and techniques have continued to evolve over the last 15 years.

Treatment options for smaller lesions without subchondral changes consist of excision, excision and curettage, and excision combined with curettage and microfracture (bone marrow stimulation). As a result of bone marrow stimulation, fibrocartilage forms as opposed to hyaline cartilage. Recent studies have shown an 82 percent success rate for the use of bone marrow stimulation in treating primary lesions.

Osteochondral lesions associated with subchondral cyst formation have less favorable results with standard arthroscopic techniques. Additional surgical techniques include retrograde drilling, trans-malleolar drilling, filling of the bony defect with autogenous cancellous bone graft, autologous chondrocyte implantation, matrix-associated chondrocyte implantation, osteochondral autograft transfer system (OATS), and autologous matrix-induced chondrogenesis.

Deciding On A Treatment Approach

Base the initial surgical planning on prior imaging studies, prior treatment methods and intraoperative chondral evaluation. Evaluate the size and location of the lesion as larger and more difficult lesions tend to require an open arthrotomy to assist with treatment. Generally, one can treat lesions < 1.0 cm with excision and curettage while larger lesions require grafting of the void. Evaluate the status of the articular surface utilizing standard arthroscopic techniques in an anterior or posterior fashion.

For instances in which the cartilage cap remains intact, retrograde drilling remains an excellent option. Retrograde drilling causes bleeding and an inflammatory response to stimulate new bone formation at the lesion site. This technique brings new vascular access to the area while avoiding damage to the healthy cartilage. One can perform this technique along with grafting or bone marrow aspirate to assist with filling of the void and stimulating growth respectively. While newer techniques involving subchondroplasty systems and techniques have recently emerged, further study regarding the results with these modalities is still pending.

Initial treatment options for lesions with chondral injury are excision, curettage and bone marrow stimulation. Subchondral drilling results in multiple bleeding sites and the release of growth factors. These growth factors form a fibrin clot, which introduces bone marrow cells that result in fibrocartilaginous tissue. For larger lesions, perform autogenous bone graft filling.

One can treat large, chronic, cystic lesions with OATS, mosaicplasty and autogenous bone grafting. Perform these techniques following excision and debridement of the lesion and the underlying subchondral bone. Then harvest these osteochondral grafts and utilize them to restore mechanical, structural and biochemical properties of the initial hyaline cartilage.

Denovo for talus lesion, University foot and ankle institute

“The DeNovo graft requires only one surgery, which surgeons can perform arthroscopically,” Dr. Baravarian .

Autologous chondrocyte implantation utilizes a two-step procedure isolating chondrocytes from a donor site that are cultivated in a laboratory. One would implant these cultured chondrocytes at the lesion site during a secondary procedure under a periosteal cover in an attempt to regenerate the area with a high percentage of hyaline-like type II cartilage. In a 2009 study assessing the use of autologous chondrocyte implantation in the ankle, Nam and colleagues noted that 91 percent of patients had a “cartilage-like” surface during second look arthroscopy at a 38-month follow-up. Mitchell and coworkers have demonstrated promising results with matrix-associated chondrocyte implantation, and it remains a viable option in the future.

Additional treatment options include cartilage allografts, DeNovo NT Natural Tissue Graft (Zimmer Biomet) and BioCartilage (Arthrex). One can utilize these allografts following initial debridement and drilling of the lesion with or without bone grafting.

A new and promising technique involves autologous matrix-induced chondrogenesis. Chondrogenesis-inducing techniques involve repair of the bone-cartilage lesion via a single step procedure that surgeons can utilize for large cystic lesions. While one study shows very good results in the talus after a one-year follow-up, more studies are needed to determine the future role of this modality.

Postoperative treatment involves non-weightbearing for four to six weeks following surgical intervention. The individual procedures require varying degrees of non-weightbearing time periods as well as varying degrees of early range of motion and physical therapy.

In Conclusion

There are multiple treatment options available for osteochondral lesions with associated subchondral cysts and one should determine the best treatment option with the assistance of MRI, CT and intraoperative findings. Utilize retrograde drilling as the primary treatment option when there is intact cartilage. When treating larger lesions, the utilization of allograft and autograft may be necessary. Newer allograft and matrix treatment methods provide promising results, and additional research will help assist and guide future treatment protocols.

Dr. Carter is an attending at the University Foot and Ankle Institute in Los Angeles. He recently completed the Silicon Valley Foot and Ankle Reconstructive Fellowship at the Palo Alto Medical Foundation in Mountain View, Calif.

Read in Podiatry Today.

Dr. Ryan Carter, DPM

Dr. Ryan Carter, DPM

Dr. Ryan Carter was born and raised in St. Louis, Missouri. He received his bachelor’s degree in Biology at the University of Missouri, Columbia, where he played on the men’s lacrosse team and was captain during his senior year.

After receiving his medical degree at Midwestern University Arizona School of Podiatric Medicine, Dr. Carter then completed a three-year surgical residency at Kaiser Permanente in Santa Clara, California. During his residency, he received comprehensive training in all aspects of the foot and ankle. During his final year of residency he served as chief resident.

In his free time, Dr. Carter enjoys running and spending time with his 10 year old corgi Kobe.
Dr. Ryan Carter, DPM

Leave a Reply

Your email address will not be published.

Over 200,000 happy UFAI patients and growing
  • CustomerSure
    You are one of the best doctors, and have the best staff, that I have ever seen. If I ever have a serious foot problem, I'll feel so much better knowing about you.
    Beverly S.
  • Yelp
    I have been suffering for a long time with pain in my toes. Thought it was just something I would have to deal with, my mom cannot even walk anymore due to her arthritis- I cried with relief to find out that Dr. Barav...
    Amanda W.
  • ZocDoc
    Dr. Yau was able to diagnose my issue during my first appointment with him, something that other doctors hadn't done after several visits and tests.
  • Yelp
    Dr. Franson is very nice and a knowledgeable physician. I had a pretty bad break years ago, and now I'm having complications. Dr. Franson found the problem and gave me answers within days! Office staff is very easy to...
    Ayla S.
  • Yelp
    Dr. Campbell is fabulous both in personality & expertise.  I went into my appointment with 4 separate issues & he knowledgeably answered all of my questions & addressed all of my concerns.  Marta who helped to schedul...
    Lisa D.
  • CustomerSure
    Very happy with the doctors I seen. Very friendly and professional. Thank you!!!!
    Brenda R.
  • ZocDoc
    Dr. Bob is excellent. He recommended a very conservative treatment, and was very knowledgeable and thorough. I am very pleased to have him as my doctor.
    William S.
  • CustomerSure
    Dr. Justin Franson, Suzanne and Jasmine are awesome!!
    Rian B.
  • Thank you for all your care and support. After 5 years of pain, you took care of things permanently for me. I can't tell you what a joy it is to be able to walk or simply pick up my kid and not be in pain. I'm foreve...
  • Yelp
    I had tendon surgery about 2 years ago at Kaiser and it was the worst experience of my life...Dr. Baravarian is a breath of fresh air! Finally!  A doctor who cares and really seems to care about your recovery! His ent...
    Mz P.
Same Day Appointments
Now Available!

Or call 877-989-9110

24 hours a day, 7 days a week